Breeds Affected: Pug
Samples Accepted: Blood, Buccal Swab
Disease Information: May-Hegglin Anomaly is a rare disorder of platelet formation (including macrothrombocytosis and thrombocytopenia) which may be mistaken for immune-mediated thrombocytopenia.
Inheritance Information: May-Hegglin Anomaly is believed to be autosomal dominant, meaning that animals with one copy of this allele will be affected. 50% of their offspring will also be affected.
The possible genotypes are:
n/n The dog is normal, and cannot produce MHA-affected offspring.
n/MHA The dog is affected with MHA, and 50% of the offspring will be affected.
MHA/MHA The dog is affected with MHA, and 100% of the offspring will also be affected.
– Affected animals (n/MHA, MHA/MHA) should not be used for breeding.
Test Information: This mutation test identifies a single base change in the MYH9 gene.
Flatland, B., Fry, M.M., Baek, S.J., Bahn, J.H., LeBlanc, C.J., Dunlap, J.R., Carroll, R.C., Kosiba, D.J., Millsaps, D.J., Schleis, S.E.: May-Hegglin anomaly in a dog. Vet Clin Pathol 40:207-14, 2011. Pubmed reference: 21554370. DOI: 10.1111/j.1939-165X.2011.00320.x.
Further information is available at the Online Mendelian Inheritance in Animals website.